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The unpleasant adverse effects of antipsychotic drugs combined with patients disbelief of having an illness which is common among individuals with schizophrenia result in high rates of nonadherence to antipsychotics in the treatment of schizophrenia first generation antipsychotic long acting injections v oral antipsychotics in they used to be called depot antipsychotics but the powers that be have renamed them long acting injectables lais presumably to help remove some of the stigma associated with their webmd explains the benefits and disadvantages of long acting schizophrenia or antipsychotic drugs that you take as a shot once or twice a monthantipsychotic long acting injections lais were introduced in the 1960s to improve treatment adherence in schizophrenia subsequently first generation antipsychotic lais became widely used in many countries recently there has been a resurgence of interest in lais that partly reflects the introduction of several second generation antipsychotic laisin a study by parellada et al 382 patients received long acting injectable risperidone rlai treatment during the early stages of their disease ie within 3 years of diagnosisthe study conducted in europe evaluated the efficacy and safety of rlai it was an open label nonrandomized and single arm multicenter study that consisted of a 6 month treatment period

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